Enchondroma is a benign hyaline cartilage tumor occurring in the medulla of bones in adults and causing destruction of the cancellous bones. It is also called chondromyxoma. Tumor cell replaces the normal bone with mineralized or unmineralized hyaline cartilage. Enchondroma has the potential to undergo malignant transformation, especially when situated in large bones, the pelvis. […]
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Osteochondroma as per WHO is ” a cartilage-capped bony projection arising in the external surface of bone containing a marrow cavity that is continuous with that of the surrounding bone.“ It is also called Exostoses Types: Multiple exostoses are seen in diaphyseal aclasis / Hereditary Multiple Exostosis Etiology Osteochondroma is considered a developmental disorder. It […]
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Multiple Myeloma is characterized by the presence of neoplastic plasma cells, which replaces bone and marrow spaces. In this scenario there is the formation of abnormal protein leads to immune deficiency and complications that hasten fatal termination. Other names are: Etiology of MM Genetic cause Chronic Inflammation Environmental cause Radiation Infection Monoclonal gammopathy of undetermined […]
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Chondrosarcoma is a malignant tumor of cartilage-producing cells which consist of a heterogeneous group of lesion with diverse morphological features and clinical behavior. Chondrosarcoma is also called as tumor with hyperglycemia It is the most common sarcoma of the bone greater than 20 years (25% of all sarcomas) WHO Classification of Chondrosarcoma Primary Chondrosarcoma 90% […]
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Ewing Sarcoma is the third most common primary tumor of bone and the second most common malignant bone tumor of late childhood and early adulthood (1 % of childhood cancers). Ewing Sarcoma belongs to the small, round, blue-cell tumors that are thought to arise from primitive mesenchymal cells. EWS gene on chromosome 22 Reciprocal translocation […]
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Osteosarcoma is the primary malignant tumor, malignant mesenchymal cells produce osteoid and/ or immature bone. It is the most common primary malignant bone tumor Classification of Osteosarcoma Etiology Previous Radiation Therapy Paget Disease of Bone Germ cell abnormality ( Li Fraumeni Syndrome p53 mutation) Werner Syndrome Rothmond Thomson Syndrome Bloom Syndrome Hereditary Retinoblastoma Age distribution: […]
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Management of Musculoskeletal Malignancy is a multidisciplinary action that involves surgical, medical, radiological, and oncological teams. Principle of Management in Musculoskeletal Malignancy Proper and Detailed Clinical History Radiological Diagnosis Then we reach a clinic-radiological diagnosis of certain Musculoskeletal Malignancy Histopathological Diagnosis There are two staging system In this staging system, primary malignant lymphoma and multiple […]
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